Zinda Health

Zinda Health

The “Fragile Engine” Problem

Why Metformin Might Not Be Enough for South Asians; how GLP-1s solve this

Omar Saleem, MD's avatar
Omar Saleem, MD
Dec 08, 2025
∙ Paid

Fair warning: this post has quite a bit about cars considering Lando’s F1 win last weekend.

For decades, the global guideline for Type 2 Diabetes has been the same: Metformin First.

The logic seems sound: “Type 2 Diabetes is a disease of insulin resistance. Metformin fixes resistance. Problem solved.”

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